Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896651 | 0.85 | PRMT5 (0.44) | USP30ACKR3CHRM1HTR6BCHE | |
| SCHEMBL7901895 | 0.82 | MEN1 (0.47) | USP30ACKR3CHRM1HTR6BCHE | |
| SCHEMBL7898331 | 0.78 | CHRM1 (0.38) | USP30ACKR3CHRM1HTR6BCHE | |
| SCHEMBL7893412 | 0.76 | ALOX5AP (0.39) | USP30ACKR3CHRM1KDM1APRMT5 | |
| SCHEMBL7898814 | 0.74 | HTR6 (0.39) | USP30ACKR3HTR6BCHE | |
| SCHEMBL7896607 | 0.74 | HTR6 (0.41) | USP30ACKR3HTR6BCHEBRD4 | |
| SCHEMBL7897488 | 0.74 | USP30 (0.42) | USP30KDM1A | |
| SCHEMBL19816138 | 0.73 | NR1H2 (0.44) | ACKR3CHRM1 | |
| SCHEMBL7896805 | 0.72 | HTR6 (0.46) | USP30ACKR3HTR6BCHEBRD4 | |
| SCHEMBL2788926 | 0.70 | HTR6 (0.42) | USP30ACKR3CHRM1HTR6BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |