Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 14/20 | 0.63 |
| ▸ | RARB | P10826 | 14/20 | 0.63 |
| ▸ | RARA | P10276 | 13/20 | 0.63 |
| ▸ | RXRA | P19793 | 4/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2914641 | 0.80 | RARB (0.68) | RARGRARBRARARXRACYP26A1 | |
| SCHEMBL30610922 | 0.79 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL84188 | 0.79 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29618929 | 0.79 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8656894 | 0.79 | RARG (0.71) | RARGRARBRARARXRACYP26A1 | |
| SCHEMBL8656889 | 0.78 | RARG (0.67) | RARGRARBRARARXRACYP26A1 | |
| SCHEMBL7265393 | 0.78 | RARG (0.63) | RARGRARBRARARXRA | |
| Bromide SCHEMBL7032662 | 0.78 | SLC6A2 (0.64) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31266609 | 0.77 | RARB (1.00) | RARGRARBRARARXRACYP26A1 | |
| SCHEMBL3453631 | 0.77 | RARB (1.00) | RARGRARBRARARXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211239-B1 | Method for treating or preventing breast cancer or leukemia using 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN) | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-04-03 | — | — | US | disclosed |
| EP-0850067-A4 | METHOD FOR TREATING CANCERS USING 6- 3- 1-ADAMANTYL]-4-HYDROXYPHENYL] | CIRD GALDERMA (FR) | 1999-12-15 | — | — | EP | disclosed |
| EP-0850067-A1 | METHOD FOR TREATING CANCERS USING 6- 3- 1-ADAMANTYL]-4-HYDROXYPHENYL] | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997003682-A1 | METHOD FOR TREATING CANCERS USING 6-[3-[1-ADAMANTYL]-4-HYDROXYPHENYL] | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. GALDERMA (FR) | 1997-02-06 | — | — | WO | disclosed |