Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F7 | P08709 | 4/20 | 0.57 |
| ▸ | F3 | P13726 | 4/20 | 0.57 |
| ▸ | F9 | P00740 | 6/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.47 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.47 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.47 |
| ▸ | CBFB | Q13951 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | F11 | P03951 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12545728 | 0.84 | F9 (0.55) | F7F3F9LRRK2KDM4E | |
| SCHEMBL23988833 | 0.80 | ALDH1A1 (0.51) | MAPTF2F11ROCK1MAP4K4 | |
| SCHEMBL4112915 | 0.79 | F9 (0.49) | F7F3F9LRRK2NPC1 | |
| SCHEMBL4115790 | 0.79 | F9 (0.59) | F7F3F9LRRK2NPC1 | |
| SCHEMBL7897327 | 0.76 | MAP4K4 (0.62) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL23279771 | 0.75 | KLKB1 (0.62) | ROCK1ROCK2 | |
| SCHEMBL5520232 | 0.74 | JAK2 (0.56) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL17436948 | 0.74 | CCNC (0.55) | KDM4EMEN1KMT2ANPC1MAPT | |
| SCHEMBL335640 | 0.73 | F7 (0.56) | F7F3F9LRRK2F2 | |
| SCHEMBL4102908 | 0.73 | F7 (0.56) | F7F3F9LRRK2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373634-B1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARM CO LTD (JP) | 2015-11-11 | — | — | EP | disclosed |
| WO-2010065717-A1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2010-06-10 | — | — | WO | disclosed |