Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14522626 | 0.83 | TRPM5 (0.44) | MAPTMEN1KMT2AKDM4ETRPM5 | |
| SCHEMBL7901471 | 0.82 | CHRNB2 (0.45) | CHRNB2CHRNA4MAPTCHRNA7CYP2A6 | |
| SCHEMBL7900671 | 0.81 | CHRNB2 (0.50) | CHRNB2CHRNA4MAPTCHRNA7CYP2A6 | |
| SCHEMBL16589775 | 0.79 | ESR1 (0.46) | CHRNB2CHRNA4MAPTNPSR1TSHR | |
| SCHEMBL7901769 | 0.73 | MEN1 (0.46) | CHRNB2CHRNA4MAPTTSHRTDP1 | |
| SCHEMBL2349856 | 0.72 | TRPM5 (0.43) | MAPTMEN1KMT2AKDM4ETRPM5 | |
| SCHEMBL156842 | 0.71 | CHRNB2 (0.56) | CHRNB2CHRNA4MAPTNPSR1TSHR | |
| SCHEMBL26703813 | 0.69 | MEN1 (0.44) | CHRNB2CHRNA4MAPTTDP1CHRNA7 | |
| SCHEMBL6986386 | 0.69 | CHRNB2 (0.46) | CHRNB2CHRNA4MAPTNPSR1TSHR | |
| SCHEMBL13964615 | 0.68 | AR (0.46) | MAPTTDP1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |