Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.46 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16585796 | 0.84 | CHRNB2 (0.51) | CHRNB2CHRNA4MEN1KMT2AMAPK1 | |
| SCHEMBL29779937 | 0.82 | PRCP (0.55) | MEN1KMT2AKDM4EMAPTRECQL | |
| SCHEMBL4978935 | 0.82 | PRCP (0.55) | MEN1KMT2AKDM4EMAPTRECQL | |
| SCHEMBL7903182 | 0.81 | CHRNB2 (0.45) | CHRNB2CHRNA4MEN1KMT2AMAPK1 | |
| SCHEMBL7901471 | 0.81 | CHRNB2 (0.45) | CHRNB2CHRNA4MEN1KMT2AMAPK1 | |
| SCHEMBL26703813 | 0.80 | MEN1 (0.44) | CHRNB2CHRNA4MEN1KMT2AKDM4E | |
| SCHEMBL3890285 | 0.78 | TSHR (0.50) | CHRNB2CHRNA4MEN1KMT2AKDM4E | |
| SCHEMBL22871239 | 0.78 | PRKCZ (0.39) | MAPTARGAA | |
| SCHEMBL29746385 | 0.78 | CYP11B2 (0.47) | CHRNB2CHRNA4MEN1KMT2AMAPK1 | |
| SCHEMBL26613583 | 0.78 | CYP11B2 (0.47) | CHRNB2CHRNA4MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |