Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PNMT | P11086 | 6/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.36 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.36 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9539807 | 0.78 | PNMT (0.43) | TDP1PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL9539813 | 0.78 | PNMT (0.43) | TDP1PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL27609029 | 0.77 | TDP1 (0.43) | TDP1PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL10841429 | 0.75 | TDP1 (0.41) | TDP1PNMTCHRNB2CHRNA4ACHE | |
| SCHEMBL7896203 | 0.73 | S100A4 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7896197 | 0.73 | S100A4 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7908209 | 0.73 | S100A4 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7896207 | 0.73 | S100A4 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL7908204 | 0.73 | S100A4 (0.45) | TDP1TSHRSMN1; SMN2GPR35HSD17B10 | |
| SCHEMBL17257605 | 0.72 | TDP1 (0.44) | TDP1TSHRSMN1; SMN2GPR35NR4A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201119-B1 | 2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-9-AMINE COMPOUNDS USEFUL AS INTERMEDIATES TO ANTIVIRALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-03-13 | — | — | US | disclosed |
| US-5371079-A | Administering to inhibit replication of HIV-1 in human cells | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-06 | — | — | US | disclosed |
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |