Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9997035 | 0.92 | KMT2A (0.55) | LRRK2GLAKMT2ALMNAGRM3 | |
| SCHEMBL9996788 | 0.89 | GLA (0.51) | LRRK2GLAKMT2ALMNAPDK2 | |
| SCHEMBL9028457 | 0.88 | LMNA (0.62) | LRRK2LMNAALDH1A1KDM4E | |
| SCHEMBL15651433 | 0.85 | HSD11B1 (0.54) | LRRK2LMNAPDK2GRM3ALDH1A1 | |
| SCHEMBL15650487 | 0.85 | HSD11B1 (0.54) | LRRK2LMNAPDK2GRM3ALDH1A1 | |
| SCHEMBL14068213 | 0.85 | HSD11B1 (0.54) | LRRK2LMNAPDK2GRM3ALDH1A1 | |
| SCHEMBL9996943 | 0.81 | GLA (0.51) | GLAKMT2ALMNAALDH1A1PKM | |
| SCHEMBL30602435 | 0.81 | HPGD (0.60) | GLAKMT2ALMNAALDH1A1 | |
| SCHEMBL15020081 | 0.81 | HPGD (0.64) | GLAKMT2ALMNAALDH1A1 | |
| SCHEMBL9997000 | 0.81 | HPGD (0.60) | GLAKMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |