Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727897 | 0.88 | ALDH1A1 (0.53) | IRAK4ALOX5POLBRORCALDH1A1 | |
| SCHEMBL7564303 | 0.85 | GAA (0.54) | IRAK4ALOX5POLBRORCALDH1A1 | |
| SCHEMBL12144981 | 0.83 | ALOX5 (0.49) | IRAK4ALOX5RORCALDH1A1MEN1 | |
| SCHEMBL31633492 | 0.83 | ALDH1A1 (0.46) | ALOX5POLBALDH1A1TSHRMEN1 | |
| SCHEMBL3884423 | 0.81 | ALDH1A1 (0.58) | ALDH1A1TSHRMAPTKDM4EUSP2 | |
| SCHEMBL6566700 | 0.81 | ALDH1A1 (0.40) | IRAK4ALOX5POLBRORCALDH1A1 | |
| SCHEMBL5863680 | 0.81 | LMNA (0.49) | IRAK4ALDH1A1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL25217998 | 0.80 | ALDH1A1 (0.56) | POLBALDH1A1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31095289 | 0.80 | ALDH1A1 (0.56) | POLBALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL3045049 | 0.79 | KMT2A (0.52) | IRAK4RORCALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214882-B1 | Benzenesulphonamide derivatives, preparation thereof and therapeutical uses thereof | SYNTHELABO (FR) | 2001-04-10 | — | — | US | disclosed |
| EP-0842148-B1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SANOFI SYNTHELABO (FR) | 2000-12-20 | — | — | EP | disclosed |
| EP-0842148-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SYNTHELABO (FR) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997006136-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SYNTHELABO (FR) | 1997-02-20 | — | — | WO | disclosed |