Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.39 |
| ▸ | HTR2A | P28223 | 6/20 | 0.39 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL373751 | 0.72 | HTR6 (0.69) | HTR2CHTR2AHTR6BRD3SLC6A4 | |
| SCHEMBL15886438 | 0.72 | KIF11 (0.46) | HTR2CHTR2AHTR6HTR7MPO | |
| SCHEMBL12209113 | 0.70 | KIF11 (0.49) | HTR2CHTR2AMPOKIF11KEAP1 | |
| SCHEMBL24486654 | 0.69 | KIF11 (0.44) | HTR2CHTR2AHTR6MPOKIF11 | |
| SCHEMBL373405 | 0.69 | HTR6 (0.74) | HTR2CHTR2AHTR6HTR7 | |
| SCHEMBL10063269 | 0.66 | KDM4E (0.51) | MPOKIF11KEAP1NFE2L2GHSR | |
| SCHEMBL6216591 | 0.66 | KEAP1 (0.44) | HTR2AMPOKIF11KEAP1NFE2L2 | |
| SCHEMBL22417993 | 0.65 | MEN1 (0.54) | HTR2AHTR6MPOKIF11KEAP1 | |
| SCHEMBL2730902 | 0.65 | KDM4E (0.50) | MPOKIF11KEAP1NFE2L2GHSR | |
| SCHEMBL890553 | 0.65 | KDM4E (0.50) | HTR2CHTR2AMPOKIF11KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010097334-A1 | DRUG COMBINATIONS CONTAINING PDE4 INHIBITORS AND NSAIDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |