Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 3/20 | 0.51 |
| ▸ | USP7 | Q93009 | 4/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004868 | 1.00 | PKM (0.51) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL1105921 | 1.00 | PKM (0.51) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL3010603 | 1.00 | PKM (0.51) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL1105755 | 1.00 | PKM (0.51) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL4004318 | 1.00 | PKM (0.51) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL4790687 | 0.91 | TACR1 (0.58) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL12647197 | 0.91 | TACR1 (0.58) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL2240106 | 0.91 | TACR1 (0.58) | PKMMAPTTACR1USP7RORC | |
| SCHEMBL5821047 | 0.90 | TACR1 (0.56) | PKMMAPTTACR1RORC | |
| SCHEMBL4756256 | 0.89 | GPR119 (0.50) | MAPTTACR1USP7GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391615-B1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2013-01-16 | — | — | EP | disclosed |
| WO-2010086259-A1 | PIPERIDINE DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-08-05 | — | — | WO | disclosed |