Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 3/20 | 0.43 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11058577 | 0.90 | KMT2A (0.38) | KMT2AMEN1USP2GRM8GRM7 | |
| Bicarbonate SCHEMBL11083414 | 0.84 | CES2 (0.40) | KMT2AMEN1USP2L3MBTL1TSHR | |
| SCHEMBL9329510 | 0.82 | POLB (0.51) | KMT2AMEN1USP2GRM8GRM7 | |
| Bicarbonate SCHEMBL29229613 | 0.79 | HTR2A (0.48) | KMT2ATSHRMAPT | |
| SCHEMBL29737271 | 0.78 | MAOA (0.52) | KMT2AMEN1USP2GRM8GRM7 | |
| SCHEMBL1077580 | 0.78 | MAOA (0.52) | KMT2AMEN1USP2GRM8GRM7 | |
| SCHEMBL10690124 | 0.76 | KMT2A (0.45) | KMT2AMEN1USP2GRM8GRM7 | |
| SCHEMBL9327353 | 0.75 | L3MBTL1 (0.41) | KMT2AMEN1USP2L3MBTL1TSHR | |
| SCHEMBL4607718 | 0.72 | — | — | |
| SCHEMBL29366966 | 0.72 | HTR2A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194121-B1 | Optical recording medium | TDK CORP. (JP) | 2001-02-27 | — | — | US | disclosed |
| US-5741623-A | CYANINE DYE | TDK CORPORATION (JP) | 1998-04-21 | — | — | US | disclosed |
| US-5670295-A | SUBSTRATE WITH RECORDING LAYER, CYANINE DYES, INDOLINE DYE AND THERMOPLASTIC RESIN | NAMBA KENRYO (JP) | 1997-09-23 | — | — | US | disclosed |
| US-5512416-A | SUBSTRATE HAVING RECORDING LAYER INCORPORATING LASER LIGHT ABSORBING CYANINE DYE | TDK CORPORATION (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5506357-A | PHOTOSTABILITY | TDK CORPORATION (JP) | 1996-04-09 | — | — | US | disclosed |
| US-5219707-A | PHOTOSTABLE CYANINE DYE AND OPTICAL RECORDING MEDIUM | TDK CORPORATION (JP) | 1993-06-15 | — | — | US | disclosed |
| EP-0176601-B1 | OPTICAL RECORDING MEDIUM | TDK Corporation (JP) | 1991-03-27 | — | — | EP | disclosed |
| EP-0181941-B1 | OPTICAL RECORDING MEDIUM | TDK Corporation (JP) | 1990-01-24 | — | — | EP | disclosed |
| EP-0182946-B1 | OPTICAL RECORDING MEDIUM | TDK Corporation (JP) | 1989-03-15 | — | — | EP | disclosed |
| US-4735889-A | DYE RECORDING LAYER, SURFACE SOLLOID COATING | TDK CORPORATION (JP) | 1988-04-05 | — | — | US | disclosed |
| EP-0147083-B1 | PHOTOSTABLE CYANINE DYE AND OPTICAL RECORDING MEDIUM | TDK Corporation (JP) | 1988-01-20 | — | — | EP | disclosed |
| US-4713314-A | MIXTURE OF CYANINE DYE WITH A COMBINATION OF CYANINE DYE CATION WITH QUENCHER ANION | TDK CORPORATION (JP) | 1987-12-15 | — | — | US | disclosed |
| EP-0182946-A1 | Optical recording medium | TDK Corporation (JP) | 1986-06-04 | — | — | EP | disclosed |
| EP-0181941-A1 | OPTICAL RECORDING MEDIUM | TDK Corporation (JP) | 1986-05-28 | — | — | EP | disclosed |
| EP-0176601-A1 | OPTICAL RECORDING MEDIUM | TDK Corporation (JP) | 1986-04-09 | — | — | EP | disclosed |
| EP-0147083-A2 | Photostable cyanine dye and optical recording medium | TDK Corporation (JP) | 1985-07-03 | — | — | EP | disclosed |