Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PKLR | P30613 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904572 | 0.85 | PKM (0.47) | ALDH1A1CYP2C19PKMHTTSMN1; SMN2 | |
| SCHEMBL7904534 | 0.82 | PKM (0.45) | ALDH1A1CYP2C19CYP3A4PKMPKLR | |
| SCHEMBL7903086 | 0.82 | CYP2C9 (0.44) | ALDH1A1CYP2D6CYP2C9PKMRAB9A | |
| SCHEMBL7906423 | 0.82 | CYP2C9 (0.44) | ALDH1A1CYP2D6CYP2C9PKMRAB9A | |
| SCHEMBL31315853 | 0.71 | PKM (1.00) | ALDH1A1PKMNPC1PKLRRAB9A | |
| SCHEMBL1722721 | 0.71 | PKM (1.00) | ALDH1A1PKMNPC1PKLRRAB9A | |
| SCHEMBL1044915 | 0.69 | HTT (0.96) | ALDH1A1CYP2D6CYP2C19PKMNPC1 | |
| SCHEMBL7903110 | 0.68 | MEN1 (0.51) | SMN1; SMN2MAPTTSHRKMT2A | |
| SCHEMBL4555472 | 0.67 | HTT (1.00) | ALDH1A1CYP2D6CYP2C19PKMNPC1 | |
| SCHEMBL8508293 | 0.67 | HTT (1.00) | ALDH1A1CYP2D6CYP2C19PKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194438-B1 | ANTITUMOR AGENTS; ANTICANCER AGENTS; FARNESYL-PROTEIN TRANSFERASE INHIBITOR | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1006113-A1 | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth | Pfizer Products Inc. (US) | 2000-06-07 | — | — | EP | disclosed |