Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913026 | 0.90 | PDE4B (0.43) | PDE4DHDAC4HDAC2HDAC8PDE4B | |
| SCHEMBL15906118 | 0.85 | ALDH1A1 (0.41) | PDE4BFFAR1SIGMAR1HTR7RXFP1 | |
| SCHEMBL3805505 | 0.81 | ALDH1A1 (0.44) | PDE4DPDE4BSIGMAR1MAPT | |
| SCHEMBL8064779 | 0.77 | PDE4D (0.42) | PDE4DHDAC4HDAC2HDAC8PDE4B | |
| SCHEMBL8066667 | 0.77 | PDE4D (0.42) | PDE4DHDAC4HDAC2HDAC8PDE4B | |
| SCHEMBL8066070 | 0.77 | HTT (0.57) | HDAC4HDAC2HDAC8LMNAHDAC3 | |
| SCHEMBL8056654 | 0.76 | PDE4D (0.43) | PDE4DHDAC4HDAC2HDAC8PDE4B | |
| SCHEMBL8066487 | 0.76 | PDE4D (0.41) | PDE4DHDAC4HDAC2HDAC8PDE4B | |
| SCHEMBL8066491 | 0.75 | PDE4D (0.41) | PDE4DHDAC4HDAC2HDAC8PDE4B | |
| SCHEMBL8066867 | 0.75 | PDE4B (0.46) | PDE4DHDAC4HDAC2HDAC8PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |