Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SDHB | P21912 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064845 | 0.87 | PDE4D (0.44) | PDE4DPDE4BCHRM3MKNK1MKNK2 | |
| SCHEMBL8055946 | 0.87 | PDE4D (0.55) | PDE4DPDE4BCHRM3MKNK1MKNK2 | |
| SCHEMBL8066667 | 0.86 | PDE4D (0.42) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL15906132 | 0.85 | PDE4B (0.43) | PDE4DPDE4BCHRM3SDHBHTR7 | |
| SCHEMBL8062936 | 0.85 | L3MBTL1 (0.39) | PDE4DPDE4BCHRM3FNTAFNTB | |
| SCHEMBL8055203 | 0.85 | PDE4D (0.44) | PDE4DPDE4BCHRM3MKNK1MKNK2 | |
| SCHEMBL7913026 | 0.85 | PDE4B (0.43) | PDE4DPDE4BHDAC4HDAC2HDAC8 | |
| SCHEMBL8056654 | 0.82 | PDE4D (0.43) | PDE4DPDE4BCHRM3HDAC4HDAC2 | |
| SCHEMBL8066487 | 0.81 | PDE4D (0.41) | PDE4DPDE4BCHRM3HDAC4HDAC2 | |
| SCHEMBL3805785 | 0.81 | TUBB4A (0.46) | PDE4DPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |