Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8054760 | 0.89 | HDAC7 (0.55) | HTTHDAC1HDAC6HDAC4HDAC7 | |
| SCHEMBL8066228 | 0.89 | HTT (0.48) | HTTTSHRMAPTTDP1 | |
| SCHEMBL8065440 | 0.88 | RXFP1 (0.57) | HDAC7POLBKMT2ARXFP1 | |
| SCHEMBL8068535 | 0.87 | HDAC7 (0.49) | HTTHDAC4HDAC7HDAC8HDAC2 | |
| SCHEMBL8071515 | 0.85 | HDAC7 (0.45) | HTTHDAC4HDAC7HDAC8HDAC2 | |
| SCHEMBL15906128 | 0.84 | HTT (0.50) | HTTHDAC1HDAC6HDAC4HDAC7 | |
| SCHEMBL8033863 | 0.83 | GAA (0.57) | HTTHDAC1HDAC6HDAC4HDAC7 | |
| SCHEMBL7913026 | 0.83 | PDE4B (0.43) | HTTHDAC4HDAC8HDAC2 | |
| SCHEMBL8064986 | 0.80 | PDE4B (0.44) | HDAC1HDAC6KMT2A | |
| SCHEMBL8053373 | 0.80 | POLB (0.46) | HDAC4HDAC8POLBHDAC2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |