SCHEMBL7904922

SCHEMBL7904922

COC(=O)Cc1ccc(SC(=O)NN(C)C)c(Cl)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.45
GAA P10253 1/20 0.45
GFER P55789 1/20 0.45
CYP4F2 P78329 1/20 0.39
CYP4A11 Q02928 1/20 0.39
LDHA P00338 1/20 0.38
HSP90AB1 P08238 1/20 0.38
TSHR P16473 2/20 0.37
MAPT P10636 2/20 0.37
HPGD P15428 2/20 0.37
NPC1 O15118 3/20 0.36
RAB9A P51151 3/20 0.36
CA2 P00918 1/20 0.36
PPARG P37231 1/20 0.36
LMNA P02545 1/20 0.36
SLC7A5 Q01650 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
TP53 P04637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
PDK2 Q15119 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3232439 0.84 ALDH1A1 (0.47) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL1865811 0.79 ALDH1A1 (0.53) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL926277 0.75 ALDH1A1 (0.51) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL14592239 0.75 ALDH1A1 (0.48) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL298044 0.74 TSHR (0.62) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL30632630 0.74 TSHR (0.62) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL7911541 0.73 ALDH1A1 (0.46) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL5531563 0.73 ALDH1A1 (0.46) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL5522622 0.72 ALDH1A1 (0.48) ALDH1A1GAAGFERCYP4F2CYP4A11
SCHEMBL13742168 0.72 MAPT (0.41) ALDH1A1CYP4F2CYP4A11LDHATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1083888-A1 MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS Advanced Medicine, Inc. (US) 2001-03-21 EP disclosed
WO-1999063983-A9 MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS ADVANCED MEDICINE INC (US) 2000-03-23 WO disclosed
WO-1999063983-A1 MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS ADVANCED MEDICINE, INC. (US) 1999-12-16 WO disclosed