SCHEMBL298044

SCHEMBL298044

COC(=O)Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.62
ALDH1A1 P00352 3/20 0.56
GAA P10253 1/20 0.56
GFER P55789 1/20 0.56
CYP4F2 P78329 1/20 0.53
CYP4A11 Q02928 1/20 0.53
SIGMAR1 Q99720 2/20 0.52
CYP1A2 P05177 1/20 0.52
CYP2D6 P10635 1/20 0.52
HSP90AB1 P08238 1/20 0.52
SMN1; SMN2 Q16637 2/20 0.51
ALOX15 P16050 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
CRHBP P24387 1/20 0.51
HTT P42858 1/20 0.51
CRHR2 Q13324 1/20 0.51
MAPK1 P28482 1/20 0.50
HSD17B10 Q99714 1/20 0.50
KDM4E B2RXH2 1/20 0.49
BLM P54132 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30632630 1.00 TSHR (0.62) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL25326335 0.92 TSHR (0.54) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL334074 0.86 GAA (0.61) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL14438957 0.86 ALDH1A1 (0.53) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL2003361 0.86 ALDH1A1 (0.66) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL10229485 0.86 ALDH1A1 (0.53) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL14216112 0.85 NPC1 (0.65) TSHRALDH1A1SIGMAR1LMNAKMT2A
SCHEMBL2982711 0.84 ALDH1A1 (0.51) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL377583 0.84 CYP4F2 (0.53) TSHRALDH1A1GAAGFERCYP4F2
SCHEMBL2434505 0.84 ALDH1A1 (0.64) TSHRALDH1A1GAAGFERCYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 248 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724435-A1 BIFUNCTIONAL AZINES CONJOGATES AS SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF Nurix Therapeutics, Inc. (US) 2026-04-15 EP disclosed
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions EMORY UNIVERSITY (US) 2026-03-24 US disclosed
US-20250282749-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. 2025-09-11 US disclosed
US-20250051344-A1 BIFUNCTIONAL SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF NURIX THERAPEUTICS, INC. 2025-02-13 US disclosed
WO-2024254532-A1 BIFUNCTIONAL AZINES CONJOGATES AS SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF NURIX THERAPEUTICS, INC. (US) 2024-12-12 WO disclosed
EP-4469445-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 EP disclosed
CN-118702710-A Method for synthesizing organoboron compound by visible light catalysis 常州大学 2024-09-27 CN disclosed
WO-2024098361-A1 ARTIFICIAL NUCLEIC ACID MOLECULE 斯微(上海)生物科技股份有限公司 2024-05-16 WO disclosed
CN-115417738-B Photo-induced alpha-hydrofluorination method for diazoaryl ester compound 哈尔滨工业大学(深圳) 2023-10-03 CN disclosed
US-20230263742-A1 A LIPID Stemirna Therapeutics Co., Ltd. (CN) 2023-08-24 US disclosed
US-4293462-A Process for the manufacture of enol derivatives, and intermediates CIBA-GEIGY CORPORATION (US) 1981-10-06 US disclosed
US-4269977-A Process for the manufacture of 8-oxo-5-thia-1-azabicyclo [4,2,0]oct-2-ene or 3-ene compounds CIBA-GEIGY CORPORATION (US) 1981-05-26 US disclosed
US-4256739-A 7β-Amino-3-thio-3-cephem-4-carboxylic acid compounds, and antibacterial compositions and methods using them CIBA-GEIGY CORPORATION (US) 1981-03-17 US disclosed
US-4255328-A CEPHALOSPORINS CIBA-GEIGY CORPORATION (US) 1981-03-10 US disclosed
US-4172832-A Mercaptoalcohols and process for their manufacture CIBA-GEIGY CORPORATION (US) 1979-10-30 US disclosed
US-4147864-A Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds CIBA-GEIGY CORPORATION (US) 1979-04-03 US disclosed
US-4110533-A PROCESS FOR THE MANUFACTURE OF ENOL DERIVATIVES CIBA-GEIGY CORPORATION (US) 1978-08-29 US disclosed
US-4013650-A PROCESS FOR THE MANUFACTURE OF 3-METHYLENE-CEPHAM COMPOUNDS CIBA-GEIGY CORPORATION (US) 1977-03-22 US disclosed
US-3989695-A 7β-Amino-cepham-3-ol-4-carboxylic acid compounds CIBA-GEIGY CORPORATION (US) 1976-11-02 US disclosed
US-3932465-A ANTIBIOTIC CIBA-GEIGY CORPORATION (US) 1976-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230263742-A1 A LIPID CETP, PLIN1, AUP1 TSHR 2301/4885ALDH1A1 1643/4885GAA 2191/4885
US-20250282749-A1 COMPOUNDS AND METHODS OF USE CYP1B1, CYP2C19, UGT1A1 TSHR 1531/4885ALDH1A1 193/4885GAA 839/4885
US-20250051344-A1 BIFUNCTIONAL SELECTIVE DEGRADERS OF SMARCA2 AND THERAPEUTIC USES THEREOF SMARCA2, SMARCE1, SMARCB1 TSHR 3787/4885ALDH1A1 3865/4885GAA 1558/4885
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions SLC6A4, HTR4, HTR1A TSHR 206/4885ALDH1A1 637/4885GAA 1519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.