Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898871 | 0.79 | MAPK1 (0.41) | MAPK1KDM4EL3MBTL1RXRALMNA | |
| SCHEMBL7904943 | 0.77 | KDM4E (0.38) | MAPK1KDM4EL3MBTL1CYP17A1CYP3A4 | |
| SCHEMBL7905069 | 0.77 | BRD4 (0.39) | MAPK1KDM4EL3MBTL1RXRACYP3A4 | |
| SCHEMBL7906282 | 0.73 | MAPK1 (0.53) | MAPK1KDM4EL3MBTL1LMNANPC1 | |
| SCHEMBL7904907 | 0.71 | MAPK1 (0.46) | MAPK1KDM4EL3MBTL1NPC1RAB9A | |
| SCHEMBL7911570 | 0.71 | MAPK1 (0.41) | MAPK1KDM4EL3MBTL1RXRALMNA | |
| SCHEMBL6905878 | 0.70 | RXRA (0.77) | MAPK1KDM4EL3MBTL1RXRACYP3A4 | |
| SCHEMBL8199065 | 0.69 | TDP1 (0.42) | KDM4EL3MBTL1RXRALMNANPC1 | |
| SCHEMBL7081365 | 0.67 | RXRA (0.49) | MAPK1KDM4EL3MBTL1RXRACYP3A4 | |
| SCHEMBL2679707 | 0.65 | MAPK1 (0.75) | MAPK1KDM4EL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |