Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904907 | 0.81 | MAPK1 (0.46) | MAPK1KDM4EL3MBTL1RAB9ANPC1 | |
| SCHEMBL8199065 | 0.76 | TDP1 (0.42) | KDM4EL3MBTL1RAB9ANPC1LMNA | |
| SCHEMBL7906285 | 0.76 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1RAB9ALMNA | |
| SCHEMBL6902498 | 0.74 | RXRA (0.60) | MAPK1KDM4EL3MBTL1 | |
| SCHEMBL7904945 | 0.73 | MAPK1 (0.44) | MAPK1KDM4EL3MBTL1RAB9ANPC1 | |
| SCHEMBL64700 | 0.71 | MAPK1 (1.00) | MAPK1KDM4EL3MBTL1P4HTM | |
| SCHEMBL69747 | 0.71 | MAPK1 (1.00) | MAPK1KDM4EL3MBTL1RAB9ANPC1 | |
| SCHEMBL29508473 | 0.71 | MAPK1 (1.00) | MAPK1KDM4EL3MBTL1RAB9ANPC1 | |
| SCHEMBL8688544 | 0.71 | MAPK1 (0.43) | MAPK1KDM4EL3MBTL1RAB9ANPC1 | |
| SCHEMBL4215082 | 0.71 | MAPK1 (0.55) | MAPK1KDM4EL3MBTL1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |