Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.64 |
| ▸ | CDC42 | P60953 | 3/20 | 0.64 |
| ▸ | RAC1 | P63000 | 3/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.64 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | RAB9A | P51151 | 1/20 | 0.64 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 5/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11198807 | 0.92 | PTGS2 (0.58) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL18096529 | 0.87 | PTGS2 (0.66) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11352958 | 0.86 | CDC42 (0.48) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11348019 | 0.86 | NPC1 (0.48) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11533036 | 0.86 | PTGS2 (0.48) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11340159 | 0.85 | CDC42 (0.47) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11535191 | 0.85 | CDC42 (0.47) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11350964 | 0.85 | CDC42 (0.47) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11346567 | 0.83 | CDC42 (0.45) | PTGS2CDC42RAC1PTGS1PAK1 | |
| SCHEMBL11442232 | 0.83 | CDC42 (0.45) | PTGS2CDC42RAC1PTGS1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000649-B1 | 5-SUBSTITUTED-1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1-CARBONITRILES AND PROCESS FOR THEIR CONVERSION TO THE CORRESPONDING 1-CARBOXYLIC ACIDS | SYNTEX (U.S.A.) INC. (US) | 1981-03-25 | — | — | EP | claimed |
| US-4140698-A | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles | SYNTEX (USA) INC. (US) | 1979-02-20 | — | — | US | claimed |
| EP-0000649-A1 | 5-substituted-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1-carbonitriles and process for their conversion to the corresponding 1-carboxylic acids | SYNTEX (U.S.A.) INC. (US) | 1979-02-07 | — | — | EP | claimed |
| US-6191285-B1 | PRODUCING KETOROLAC TROMETHAMINE IN A THREE-PART SOLVENT SYSTEM, I.E., IN THE PRESENCE OF A LOWER ALKYL ALCOHOL, A LOWER ALKYL ACETATE AND WATER BY REACTING KETOROLAC ACID AND TROMETHAMINE | ABBOTT LABORATORIES | 2001-02-20 | — | — | US | disclosed |
| EP-0053021-B1 | PROCESS FOR 5-AROYLATION OF 1,2-DIHYDRO-3H-PYRROLO(1,2-A)PYRROLE-1-CARBOXYLIC ESTERS AND NITRILES | SYNTEX (U.S.A.) INC. (US) | 1985-05-02 | — | — | EP | disclosed |
| US-4353829-A | AROYL MORPHOLIDE REAGENT | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |
| EP-0053021-A2 | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1-carboxylic esters and nitriles | SYNTEX (U.S.A.) INC. (US) | 1982-06-02 | — | — | EP | disclosed |
| US-4140698-A | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles | SYNTEX (USA) INC. (US) | 1979-02-20 | — | — | US | disclosed |
| EP-0000649-A1 | 5-substituted-1,2-dihydro-3H-pyrrolo(1,2-a)pyrrole-1-carbonitriles and process for their conversion to the corresponding 1-carboxylic acids | SYNTEX (U.S.A.) INC. (US) | 1979-02-07 | — | — | EP | disclosed |