Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912345 | 0.87 | KMO (0.57) | KMOSLC6A4SLC6A3HSD11B1 | |
| SCHEMBL7905632 | 0.87 | KMO (0.57) | KMOSLC6A4SLC6A3HSD11B1 | |
| SCHEMBL19660202 | 0.79 | KMO (0.56) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7868632 | 0.78 | KMO (0.68) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7405864 | 0.78 | KMO (0.68) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7905593 | 0.78 | KMO (0.46) | KMOSLC6A4SLC6A3HPGDTAS1R3 | |
| Hydrochloric Acid SCHEMBL7899395 | 0.76 | KMO (0.69) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7907186 | 0.74 | KMO (0.57) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7908245 | 0.74 | KMO (0.57) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7403249 | 0.71 | KMO (0.74) | KMOHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |