Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GRN | P28799 | 1/20 | 0.41 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907206 | 0.86 | KMO (0.56) | KMOSLC6A4SLC6A3GRNSORT1 | |
| SCHEMBL7907182 | 0.86 | KMO (0.56) | KMOSLC6A4SLC6A3GRNSORT1 | |
| SCHEMBL7899412 | 0.86 | KMO (0.56) | KMOSLC6A4SLC6A3GRNSORT1 | |
| SCHEMBL7912394 | 0.80 | TAS1R3 (0.47) | KMOTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL7899441 | 0.80 | TAS1R3 (0.47) | KMOTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL7905591 | 0.78 | KMO (0.48) | KMOTAS1R3TAS1R1SLC6A4SLC6A3 | |
| SCHEMBL19660202 | 0.77 | KMO (0.56) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7405864 | 0.76 | KMO (0.68) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7868632 | 0.76 | KMO (0.68) | KMOSLC6A4SLC6A3HPGD | |
| SCHEMBL7799556 | 0.75 | ALDH1A1 (0.48) | TAS1R3TAS1R1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |