Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905801 | 1.00 | MAPK1 (0.39) | MAPK1ALDH1A1HSD17B10THRBPKM | |
| SCHEMBL344140 | 0.74 | TSHR (0.35) | ALDH1A1TSHR | |
| SCHEMBL16077366 | 0.74 | RARB (0.36) | MAPK1RARBTSHR | |
| SCHEMBL17446001 | 0.73 | CYP2D6 (0.36) | MAPK1RARBTDP1TSHR | |
| SCHEMBL18811947 | 0.73 | ALDH1A1 (0.37) | MAPK1ALDH1A1CA1CA12CA2 | |
| SCHEMBL7913107 | 0.72 | NAAA (0.41) | THRBRARBTSHR | |
| SCHEMBL7913105 | 0.72 | NAAA (0.41) | THRBRARBTSHR | |
| SCHEMBL1696075 | 0.72 | RARB (0.43) | MAPK1RARBTDP1 | |
| SCHEMBL1838062 | 0.71 | ALDH1A1 (0.35) | MAPK1ALDH1A1CA1CA12CA2 | |
| SCHEMBL6000229 | 0.71 | HMGCR (0.38) | MAPK1ALDH1A1THRBTHRATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274716-B1 | COMPRISE DISACCHARIDES AND TRISACCHARIDES COVALENTLY BONDED TO LIPID OR LIPID MIMETIC THROUGH PHOSPHOROUS LINKAGE; SCREENED FOR ANTI-MICROBIAL ACTIVITY BY CONTACTING THEM WITH CULTURE OF MICROBES AND MONITORING THE GROWTH RATE | ADVANCED MEDICINE, INC. | 2001-08-14 | — | — | US | disclosed |
| US-6207820-B1 | SOLID PHASE SYNTHESIS BY LINKING ACCEPTOR MONOSACCHARIDE TO SUPPORT FORMING CARBOXYLATE OR CARBOXYAMIDE LINKAGE, COVALENTLY LINKING DONOR SACCHARIDE BY O-GLYCOSIDIC LINKAGE, COUPLING LIPOPHOSPHOGLYCERATE MIMETIC, CLEAVING FROM SUPPORT | INCARA RESEARCH LABORATORIES | 2001-03-27 | — | — | US | disclosed |
| EP-1047703-A1 | A COMBINATORIAL LIBRARY OF MOENOMYCIN ANALOGS AND METHODS OF PRODUCING SAME | Incara Pharmaceutical Corp. (US) | 2000-11-02 | — | — | EP | disclosed |
| US-6114309-A | REACTION PRODUCT OF MONOSACCHARIDE, DISACCHARIDE AND LIPOPHOSPHOGLYCERATE MINETIC | INCARA RESEARCH LABORATORIES (US) | 2000-09-05 | — | — | US | disclosed |
| WO-1999026956-A1 | A COMBINATORIAL LIBRARY OF MOENOMYCIN ANALOGS AND METHODS OF PRODUCING SAME | INCARA PHARMACEUTICAL CORP. (US) | 1999-06-03 | — | — | WO | disclosed |