Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 10/20 | 0.37 |
| ▸ | PPARG | P37231 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907791 | 0.89 | PREP (0.40) | PREPPPARAPPARG | |
| SCHEMBL3374108 | 0.81 | PPARG (0.49) | PPARAPPARGKDM4EMEN1ALDH1A1 | |
| SCHEMBL3375358 | 0.80 | PPARA (0.52) | PPARAPPARGKDM4EMEN1ALDH1A1 | |
| SCHEMBL3368282 | 0.79 | MAPT (0.46) | PPARAKDM4EALDH1A1MAPT | |
| SCHEMBL820915 | 0.78 | PPARA (0.49) | PPARAPPARGKDM4EGAA | |
| SCHEMBL7911555 | 0.76 | PPARA (0.50) | PPARAPPARG | |
| SCHEMBL6602368 | 0.76 | DCK (0.53) | PPARAPPARGLMNAMAPT | |
| SCHEMBL3372455 | 0.76 | APEX1 (0.47) | PPARAPPARGKDM4EMEN1ALDH1A1 | |
| SCHEMBL4889434 | 0.76 | RARA (0.51) | PPARAPPARGALDH1A1GAAMAPT | |
| SCHEMBL1436076 | 0.75 | RARA (0.50) | PPARAPPARGALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |