Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 6/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14826749 | 1.00 | POLB (0.33) | POLBPDE9AKDM4EALDH1A1MAPT | |
| SCHEMBL12044353 | 0.91 | BCL2 (0.38) | BCL2NR1D1 | |
| SCHEMBL7902984 | 0.89 | TRAP1 (0.37) | POLBPDE9AKDM4EALDH1A1MAPT | |
| SCHEMBL10186501 | 0.87 | KMT2A (0.41) | POLBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7899542 | 0.82 | TRPM8 (0.36) | POLBALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL7905949 | 0.80 | TP53 (0.35) | MAPT | |
| SCHEMBL7907359 | 0.79 | HSP90AA1 (0.41) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL7912548 | 0.79 | ROCK2 (0.43) | PDE9AALDH1A1HPGDTDP1MEN1 | |
| SCHEMBL7907361 | 0.78 | KRAS (0.37) | POLBKDM4EALDH1A1MAPTG6PD | |
| SCHEMBL7908855 | 0.74 | PDE2A (0.37) | MAPTHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010101230-A1 | QUINOXALINE COMPOUNDS | アステラス製薬株式会社 (JP) | 2010-09-10 | — | — | WO | disclosed |