Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1650258 | 0.71 | KDM4E (0.43) | ALDH1A1MAPTHSD17B10KDM4ECYP1A2 | |
| SCHEMBL7906503 | 0.67 | PDE10A (0.30) | PDE10A | |
| SCHEMBL8758380 | 0.64 | KDM4E (0.46) | ALDH1A1MAPTKDM4EMEN1CYP3A4 | |
| SCHEMBL5677317 | 0.63 | HMGCR (0.40) | ESR1ESR2MAPTMEN1CYP3A4 | |
| SCHEMBL5919773 | 0.61 | PRKCI (0.46) | ESR1ESR2MAPTMEN1CYP3A4 | |
| SCHEMBL5549149 | 0.60 | ESR1 (0.47) | SREBF2ESR1ESR2ALDH1A1MAPT | |
| SCHEMBL16906811 | 0.60 | LMNA (0.37) | ESR1ESR2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL3480455 | 0.59 | ALDH1A1 (0.41) | ALDH1A1MAPTHSD17B10ALOX12 | |
| SCHEMBL8783926 | 0.58 | ALDH1A1 (0.46) | ALDH1A1MAPTHSD17B10KDM4EMEN1 | |
| SCHEMBL275514 | 0.57 | CYP3A4 (0.46) | SREBF2ALDH1A1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6193954-B1 | ADMINISTERING THERAPEUTICALLY EFFECTIVE AMOUNT OF DRUG DOPAMINE AGONIST, A PROPELLANT AND POLOXAME TO PATIENT | ABBOTT LABORATORIES | 2001-02-27 | — | — | US | disclosed |