SCHEMBL7907015

SCHEMBL7907015

CS(=O)(=O)Nc1ccc(CCCCNCc2ccccc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 6/20 0.64
BCHE P06276 1/20 0.53
DRD2 P14416 1/20 0.52
DRD4 P21917 1/20 0.52
DRD3 P35462 1/20 0.52
MAOA P21397 1/20 0.51
POLB P06746 1/20 0.51
GRIN1 Q05586 1/20 0.51
KCNH2 Q12809 1/20 0.51
GRIN2B Q13224 1/20 0.51
GNRHR P30968 1/20 0.51
CHRM2 P08172 1/20 0.50
ADRB2 P07550 1/20 0.50
ADRB1 P08588 1/20 0.50
ADRB3 P13945 1/20 0.50
HPGD P15428 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.49
AR P10275 1/20 0.49
RAB9A P51151 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL9445091 0.89 GAA (0.62) BCHEDRD2DRD4DRD3ADRB2
SCHEMBL9763725 0.86 DRD2 (0.51) SIGMAR1BCHEDRD2DRD4DRD3
SCHEMBL8761789 0.82 GRIN1 (0.55) DRD3POLBGRIN1KCNH2GRIN2B
SCHEMBL6014422 0.80 SIGMAR1 (1.00) SIGMAR1BCHEMAOACHRM2MEN1
SCHEMBL27491316 0.80 KDM4E (0.54) DRD3POLBGRIN1KCNH2GRIN2B
SCHEMBL10529695 0.79 HPGD (0.62) SIGMAR1DRD3POLBGRIN1KCNH2
SCHEMBL9762627 0.79 SIGMAR1 (0.52) SIGMAR1BCHEMAOACHRM2ADRB3
SCHEMBL6014369 0.78 SIGMAR1 (1.00) SIGMAR1BCHEMAOACHRM2MEN1
SCHEMBL7756958 0.78 SIGMAR1 (1.00) SIGMAR1BCHEMAOACHRM2MEN1
SCHEMBL8097260 0.78 SIGMAR1 (1.00) SIGMAR1BCHEMAOACHRM2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6197975-B1 7-AZABICYCLO(2.2.1)HEPTANE-7-CARBONYL-SUBSTITUTED 2-PHENYLINDOLE DERIVATIVES; SEXUAL DISORDERS; ANTICARCINOGENIC AGENTS MERCK & CO. , INC. 2001-03-06 US disclosed
EP-0868178-A4 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 2000-03-29 EP disclosed
EP-0882040-A4 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO INC (US) 1999-02-10 EP disclosed
EP-0882040-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (US) 1998-12-09 EP disclosed
EP-0868178-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE Merck & Co., Inc. (US) 1998-10-07 EP disclosed
US-5756507-A TREATING SEX HORMONE RELATED DISORDERS MERCK & CO., INC. (US) 1998-05-26 US disclosed
WO-1997021707-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1997-06-19 WO disclosed
WO-1997021435-A1 ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE MERCK & CO., INC. (US) 1997-06-19 WO disclosed