SCHEMBL7907219

SCHEMBL7907219

COc1cccc(Cl)c1-c1cc(Cl)c(Cl)cc1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.49
HSP90AB1 P08238 2/20 0.49
GRIA1 P42261 1/20 0.47
CACNG8 Q8WXS5 1/20 0.47
NQO2 P16083 1/20 0.44
WEE1 P30291 2/20 0.41
CHEK1 O14757 1/20 0.41
TOP1 P11387 1/20 0.41
AR P10275 2/20 0.40
EIF4E P06730 1/20 0.40
MAPK1 P28482 1/20 0.39
AHR P35869 1/20 0.39
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 1/20 0.38
POLQ O75417 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4220947 0.81 KMT2A (0.49) HSP90AA1HSP90AB1GRIA1CACNG8TOP1
SCHEMBL4453300 0.80 AHR (0.55) GRIA1CACNG8MAPK1AHRALDH1A1
SCHEMBL29370249 0.80 AHR (0.55) GRIA1CACNG8MAPK1AHRALDH1A1
SCHEMBL9734016 0.78 MAPK1 (0.41) HSP90AA1HSP90AB1GRIA1CACNG8NQO2
SCHEMBL4225651 0.76 HSP90AA1 (0.47) HSP90AA1HSP90AB1GRIA1CACNG8TOP1
SCHEMBL23740426 0.76 HSP90AA1 (0.44) HSP90AA1HSP90AB1GRIA1CACNG8WEE1
SCHEMBL277658 0.76 HSP90AA1 (0.47) HSP90AA1HSP90AB1GRIA1CACNG8WEE1
SCHEMBL21638244 0.76 MAPK14 (0.44) HSP90AA1HSP90AB1GRIA1CACNG8WEE1
SCHEMBL22760437 0.75 DHPS (0.44) HSP90AA1HSP90AB1GRIA1CACNG8TOP1
SCHEMBL4228781 0.75 APP (0.53) HSP90AA1HSP90AB1TOP1ARALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6204005-B1 ACCURATE AND SENSITIVE QUALITATIVE OR QUANTITATIVE ANALYSIS BY INCUBATING ANTIBODIES AND COMPETITOR OF DEFINED STRUCTURE IN PRESENCE OF TEST SAMPLE, THEN DETECTING CONGENER ECOCHEM RESEARCH, INC. 2001-03-20 US disclosed