Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.60 |
| ▸ | GRN | P28799 | 1/20 | 0.56 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908744 | 1.00 | KMO (0.60) | KMOGRNSORT1KDM4EGAA | |
| SCHEMBL7907186 | 0.86 | KMO (0.57) | KMOGRNSORT1KDM4EGAA | |
| SCHEMBL7908245 | 0.86 | KMO (0.57) | KMOGRNSORT1KDM4EGAA | |
| SCHEMBL7908730 | 0.83 | GRN (0.60) | KMOGRNSORT1KDM4EGAA | |
| SCHEMBL7907139 | 0.83 | GRN (0.60) | KMOGRNSORT1KDM4EGAA | |
| SCHEMBL7907182 | 0.82 | KMO (0.56) | KMOGRNSORT1MAPTSLC6A4 | |
| SCHEMBL7899412 | 0.82 | KMO (0.56) | KMOGRNSORT1MAPTSLC6A4 | |
| SCHEMBL7907206 | 0.82 | KMO (0.56) | KMOGRNSORT1MAPTSLC6A4 | |
| SCHEMBL7905632 | 0.81 | KMO (0.57) | KMOGRNSORT1KDM4ERAB9A | |
| SCHEMBL7912345 | 0.81 | KMO (0.57) | KMOGRNSORT1KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |