Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 1/20 | 0.60 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.60 |
| ▸ | KMO | O15229 | 4/20 | 0.57 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907139 | 1.00 | GRN (0.60) | GRNSORT1KMOCA1CA2 | |
| SCHEMBL8152947 | 0.84 | GRN (0.52) | GRNSORT1KMOCA1CA2 | |
| SCHEMBL7908744 | 0.83 | KMO (0.60) | GRNSORT1KMOKDM4EGAA | |
| SCHEMBL7907227 | 0.83 | KMO (0.60) | GRNSORT1KMOKDM4EGAA | |
| SCHEMBL7907186 | 0.81 | KMO (0.57) | GRNSORT1KMOKDM4EGAA | |
| SCHEMBL7908245 | 0.81 | KMO (0.57) | GRNSORT1KMOKDM4EGAA | |
| SCHEMBL7908690 | 0.80 | KMO (0.56) | KMO | |
| SCHEMBL7912399 | 0.80 | KMO (0.56) | KMO | |
| SCHEMBL7907206 | 0.80 | KMO (0.56) | GRNSORT1KMOCA1CA2 | |
| SCHEMBL7899412 | 0.80 | KMO (0.56) | GRNSORT1KMOCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0931056-A1 | N-SUBSTITUTED-2-AMINO-4-PHENYL-4-OXO-BUTANOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITORY ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1999-07-28 | — | — | EP | claimed |
| WO-1998009938-A1 | N-SUBSTITUTED-2-AMINO-4-PHENYL-4-OXO-BUTANOIC ACID DERIVATIVES WITH KYNURENINE-3-HYDROXYLASE INHIBITORY ACTIVITY | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-03-12 | — | — | WO | claimed |
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |