Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.56 |
| ▸ | GRN | P28799 | 1/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907206 | 1.00 | KMO (0.56) | KMOGRNSORT1CA1CA2 | |
| SCHEMBL7907182 | 1.00 | KMO (0.56) | KMOGRNSORT1CA1CA2 | |
| SCHEMBL7905593 | 0.86 | KMO (0.46) | KMOGRNSORT1SLC6A4SLC6A3 | |
| SCHEMBL7899441 | 0.86 | TAS1R3 (0.47) | KMOALDH1A1LMNAHTT | |
| SCHEMBL7912394 | 0.86 | TAS1R3 (0.47) | KMOALDH1A1LMNAHTT | |
| SCHEMBL7907136 | 0.83 | ERCC5 (0.49) | KMOGRNSORT1SLC6A4SLC6A3 | |
| SCHEMBL7908710 | 0.83 | ERCC5 (0.49) | KMOGRNSORT1SLC6A4SLC6A3 | |
| SCHEMBL7908375 | 0.83 | CES2 (0.40) | SLC6A3MAPT | |
| SCHEMBL7908401 | 0.83 | CES2 (0.40) | SLC6A3MAPT | |
| SCHEMBL7899386 | 0.83 | CES2 (0.40) | SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |