Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 8/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18271503 | 0.81 | PLA2G2A (0.56) | AKR1C2AKR1C3ARAKR1C4PTGS1 | |
| SCHEMBL8649350 | 0.81 | AKR1C2 (0.67) | AKR1C2AKR1C3ARAKR1C4PTGS1 | |
| SCHEMBL8367147 | 0.80 | AKR1C2 (0.58) | AKR1C2AKR1C3ARAKR1C4PTGS1 | |
| SCHEMBL9956776 | 0.78 | KDM4E (0.52) | TSHRNPSR1MAPTMEN1KMT2A | |
| SCHEMBL8532819 | 0.77 | ADRB2 (0.56) | AKR1C2AKR1C3ARAKR1C4PTGS1 | |
| SCHEMBL8366206 | 0.77 | KDM4E (0.55) | AKR1C2AKR1C3AKR1C4PTGS1LMNA | |
| SCHEMBL21095824 | 0.77 | MAPT (0.46) | AKR1C2AKR1C3ARAKR1C4PTGS1 | |
| SCHEMBL9959992 | 0.74 | MAPT (0.49) | CYP1A2NPSR1CYP2D6MAPTMEN1 | |
| SCHEMBL21096050 | 0.74 | AKR1C3 (0.65) | AKR1C2AKR1C3ARAKR1C4PTGS1 | |
| SCHEMBL12926010 | 0.74 | MAPT (0.59) | CYP1A2NPSR1CYP2D6MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068338-A2 | ENHANCED PRODRUG ACTIVATION | Oxford Biomedica (UK) Limited (GB) | 2001-01-17 | — | — | EP | disclosed |
| EP-0988057-A1 | DRUG TARGETING | Theramark Limited (GB) | 2000-03-29 | — | — | EP | disclosed |
| WO-1999045127-A2 | ENHANCED PRODRUG ACTIVATION | OXFORD BIOMEDICA (UK) LIMITED (GB) | 1999-09-10 | — | — | WO | disclosed |
| WO-1998035701-A1 | DRUG TARGETING | THERAMARK LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |