Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 12/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | IL2 | P60568 | 2/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.48 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903775 | 0.87 | KIT (0.73) | KITDYRK1APIK3CASLC2A1 | |
| SCHEMBL7907903 | 0.86 | KIT (0.70) | MAP3K11KITDYRK1APIK3CASLC2A1 | |
| SCHEMBL7910407 | 0.85 | MAP3K11 (0.47) | MAP3K11KITDYRK1APIK3CAMAP4K1 | |
| SCHEMBL7899036 | 0.85 | KIT (0.63) | MAP3K11KITDYRK1APIK3CASLC2A1 | |
| SCHEMBL7908989 | 0.84 | MAP3K11 (0.63) | MAP3K11KITDYRK1APIK3CA | |
| SCHEMBL7907491 | 0.84 | AXL (0.64) | MAP3K11KIT | |
| SCHEMBL7906025 | 0.83 | MAP3K11 (0.69) | MAP3K11KITDYRK1APIK3CAIL2 | |
| SCHEMBL7905041 | 0.83 | NTRK1 (0.63) | MAP3K11KITDYRK1APIK3CA | |
| SCHEMBL7906551 | 0.83 | KIT (0.57) | MAP3K11KITDYRK1APIK3CA | |
| SCHEMBL14232640 | 0.81 | SLC2A1 (0.48) | KITDYRK1APIK3CASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149950-A2 | BICYCLIC HETEROARYL KINASE INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2011-12-01 | — | — | WO | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |