Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 14/20 | 0.63 |
| ▸ | HTR1A | P08908 | 11/20 | 0.63 |
| ▸ | HTR6 | P50406 | 11/20 | 0.51 |
| ▸ | HTR2A | P28223 | 8/20 | 0.51 |
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL791263 | 0.81 | DRD2 (0.58) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL792805 | 0.80 | DRD2 (0.53) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL15064357 | 0.80 | HTR7 (0.65) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL798604 | 0.79 | HTR7 (0.57) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL798515 | 0.79 | DRD2 (0.54) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL792919 | 0.78 | HTR1A (0.67) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL791128 | 0.78 | HTR7 (1.00) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL792349 | 0.78 | HTR7 (0.71) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL792428 | 0.78 | HTR7 (0.56) | HTR7HTR1AHTR6HTR2ADRD2 | |
| SCHEMBL15064829 | 0.77 | HTR7 (0.64) | HTR7HTR1AHTR6HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616440-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | Adamed sp. z o.o. (PL) | 2013-07-24 | — | — | EP | claimed |
| US-20130172365-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z.O.O. (PL) | 2013-07-04 | — | — | US | claimed |
| CN-103108864-A | Arylsulfonamides for treatment of CNS disorders | ADAMED SP ZOO | 2013-05-15 | — | — | CN | claimed |
| WO-2012035123-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z O.O. (PL) | 2012-03-22 | — | — | WO | claimed |
| US-9120767-B2 | Arylosulfonamides for the treatment of CNS diseases | ADAMED SP. Z.O.O. (PL) | 2015-09-01 | — | — | US | disclosed |
| US-20140336200-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z O.O. (PL) | 2014-11-13 | — | — | US | disclosed |
| US-8822517-B2 | Arylosulfonamides for the treatment of CNS diseases | ADAMED SP. Z O.O. (PL) | 2014-09-02 | — | — | US | disclosed |
| US-20130172365-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z.O.O. (PL) | 2013-07-04 | — | — | US | disclosed |
| CN-103108864-A | Arylsulfonamides for treatment of CNS disorders | ADAMED SP ZOO | 2013-05-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336200-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ARSA, PMP22, STS | HTR7 1419/4885HTR1A 1354/4885HTR6 1131/4885 |
| US-20130172365-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ARSA, PMP22, STS | HTR7 1419/4885HTR1A 1354/4885HTR6 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.