SCHEMBL7907684

SCHEMBL7907684

COc1cc(C)c(N=C2NC(=O)[N+](c3c(C)cc(OC)cc3C)(c3c(C)cc(OC)cc3C)C2=Nc2c(C)cc(OC)cc2C)c(C)c1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 1/20 0.30
PDE3A Q14432 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7925120 0.77 POLB (0.39)
SCHEMBL6872181 0.63 PDE3B (0.47) PDE3BPDE3A
SCHEMBL6872187 0.63 PDE3B (0.47) PDE3BPDE3A
SCHEMBL6430032 0.59 CYP19A1 (0.36)
SCHEMBL6430034 0.59 CYP19A1 (0.36)
SCHEMBL10906204 0.57 ALDH1A1 (0.40)
SCHEMBL6434245 0.57 ALDH1A1 (0.36)
SCHEMBL6434244 0.57 ALDH1A1 (0.36)
SCHEMBL2955343 0.56 ALDH1A1 (0.56)
SCHEMBL10829208 0.55 PGR (0.42) PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303720-B1 E.G., NICKEL COMPLEX OF 2,3-BIS(2,6-DIMETHYLPHENYLIMINO)-(1,4)-DITHIANE EASTMAN CHEMICAL COMPANY 2001-10-16 US disclosed
EP-1082362-A1 SUPPORTED GROUP 8-10 TRANSITION METAL OLEFIN POLYMERIZATION CATALYSTS EASTMAN CHEMICAL COMPANY (US) 2001-03-14 EP disclosed
EP-0973762-A2 OLEFIN POLYMERIZATION CATALYSTS CONTAINING GROUP 8-10 TRANSITION METALS, BIDENTATE LIGANDS , PROCESSES EMPLOYING SUCH CATALYSTS AND POLYMERS OBTAINED THEREFROM EASTMAN CHEMICAL COMPANY (US) 2000-01-26 EP disclosed
WO-1999062968-A1 SUPPORTED GROUP 8-10 TRANSITION METAL OLEFIN POLYMERIZATION CATALYSTS EASTMAN CHEMICAL COMPANY (US) 1999-12-09 WO disclosed
WO-1998040374-A2 OLEFIN POLYMERIZATION CATALYSTS CONTAINING GROUP 8-10 TRANSITION METALS, BIDENTATE LIGANDS, PROCESSES EMPLOYING SUCH CATALYSTS AND POLYMERS OBTAINED THEREFROM EASTMAN CHEMICAL COMPANY (US) 1998-09-17 WO disclosed