Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | BRS3 | P32247 | 4/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2341888 | 0.91 | HTR2A (0.53) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL2336671 | 0.90 | NPSR1 (0.44) | HTR2AHTR2CHTR2BALDH1A1 | |
| SCHEMBL2341806 | 0.88 | CLPP (0.46) | HTR2AHTR2CHTR2BC5AR1 | |
| SCHEMBL2333354 | 0.87 | KDM4E (0.45) | KMT2AMEN1HTR2AHTR2CHTR2B | |
| SCHEMBL2334932 | 0.81 | C5AR1 (0.43) | KMT2AMEN1BRS3C5AR1PARP1 | |
| SCHEMBL16034465 | 0.77 | KMT2A (0.53) | KMT2AMEN1BRS3C5AR1PARP1 | |
| SCHEMBL183618 | 0.75 | P2RX7 (0.53) | KMT2AMEN1C5AR1PARP1TNKS2 | |
| Hydrochloric Acid SCHEMBL6298078 | 0.74 | P2RX7 (0.52) | KMT2AMEN1C5AR1PARP1TNKS2 | |
| SCHEMBL22720571 | 0.74 | KMT2A (0.48) | KMT2AMEN1C5AR1PARP1TNKS2 | |
| SCHEMBL4147065 | 0.74 | C5AR1 (0.57) | KMT2AMEN1C5AR1PARP1TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053825-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-14 | — | — | WO | disclosed |