Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8382230 | 0.95 | CA12 (0.46) | NPC1RAB9AMAPTHTTNAMPT | |
| SCHEMBL7913448 | 0.91 | GAA (0.45) | GAANAMPT | |
| SCHEMBL8384540 | 0.90 | NPC1 (0.46) | NPC1RAB9AMAPTHTT | |
| SCHEMBL7909721 | 0.89 | POLB (0.46) | NPC1RAB9AGAAMAPTHTT | |
| SCHEMBL7913440 | 0.88 | ALDH1A1 (0.49) | GAAMAPT | |
| SCHEMBL7913458 | 0.88 | SMN1; SMN2 (0.52) | GAAMAPTHTT | |
| SCHEMBL8381689 | 0.84 | EPHX2 (0.53) | NPC1RAB9AMAPTHTTNAMPT | |
| SCHEMBL7913438 | 0.82 | GAA (0.43) | GAAHTT | |
| SCHEMBL8386238 | 0.82 | HTT (0.43) | RAB9AHTTNAMPT | |
| SCHEMBL8384343 | 0.82 | POLB (0.48) | NPC1RAB9AMAPTHTTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |