Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386238 | 0.92 | HTT (0.43) | ALDH1A1KMT2ANAMPTTDP1EPHX2 | |
| SCHEMBL7907940 | 0.91 | NPC1 (0.45) | GAANAMPT | |
| SCHEMBL7907928 | 0.90 | GAA (0.45) | GAASMYD3KMT2ANAMPTEPHX2 | |
| SCHEMBL7913440 | 0.88 | ALDH1A1 (0.49) | GAAALDH1A1KMT2APOLB | |
| SCHEMBL7913458 | 0.87 | SMN1; SMN2 (0.52) | GAAALDH1A1KMT2AEPHX2POLB | |
| SCHEMBL8382230 | 0.87 | CA12 (0.46) | NAMPT | |
| SCHEMBL8385319 | 0.84 | NAMPT (0.47) | KMT2ANAMPTEPHX2POLB | |
| SCHEMBL8384540 | 0.83 | NPC1 (0.46) | TDP1POLB | |
| SCHEMBL7913438 | 0.82 | GAA (0.43) | GAAALDH1A1SMYD3KMT2A | |
| SCHEMBL8386581 | 0.82 | FAAH (0.44) | ALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |