Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381940 | 0.92 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1L3MBTL1NPSR1MAPT | |
| SCHEMBL7913440 | 0.92 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1GAAMAPTTP53 | |
| SCHEMBL7909446 | 0.90 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL7907940 | 0.88 | NPC1 (0.45) | GAAMAPTHTT | |
| SCHEMBL7913448 | 0.87 | GAA (0.45) | ALDH1A1GAAKMT2APOLBEPHX2 | |
| SCHEMBL8380945 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1L3MBTL1MAPTKMT2A | |
| SCHEMBL7913420 | 0.84 | LMNA (0.49) | SMN1; SMN2ALDH1A1GAAMAPTKMT2A | |
| SCHEMBL8382230 | 0.83 | CA12 (0.46) | SMN1; SMN2MAPTHTT | |
| SCHEMBL7913438 | 0.82 | GAA (0.43) | SMN1; SMN2ALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL8381010 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1L3MBTL1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |