Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROS1 | P08922 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.54 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485845 | 0.82 | TGM2 (0.53) | LRRK2BRPF1CREBBPKMT2ALMNA | |
| SCHEMBL5063224 | 0.82 | NTRK1 (0.52) | LRRK2BRPF1CREBBPKMT2AMEN1 | |
| SCHEMBL14765191 | 0.81 | CREBBP (0.61) | ROS1CDK5ACVR1LRRK2BRPF1 | |
| SCHEMBL5063195 | 0.77 | BRPF1 (0.67) | ACVR1LRRK2BRPF1CREBBPCSNK1G1 | |
| SCHEMBL30592979 | 0.77 | BRPF1 (0.67) | ACVR1LRRK2BRPF1CREBBPCSNK1G1 | |
| SCHEMBL7227738 | 0.77 | BRPF1 (0.67) | ACVR1LRRK2BRPF1CREBBPCSNK1G1 | |
| SCHEMBL8339851 | 0.76 | ROS1 (0.49) | ROS1CDK5ACVR1LRRK2CSNK1G1 | |
| SCHEMBL12241460 | 0.75 | KDM4E (0.44) | ROS1CDK5ACVR1LRRK2KMT2A | |
| SCHEMBL12240953 | 0.75 | KDM4E (0.44) | ROS1CDK5ACVR1LRRK2KMT2A | |
| SCHEMBL12241449 | 0.75 | KDM4E (0.44) | ROS1CDK5ACVR1LRRK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201119-B1 | 2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-9-AMINE COMPOUNDS USEFUL AS INTERMEDIATES TO ANTIVIRALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-03-13 | — | — | US | disclosed |
| US-5371079-A | Administering to inhibit replication of HIV-1 in human cells | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-06 | — | — | US | disclosed |
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |