Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 6/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905131 | 0.90 | MAP4K1 (0.54) | MAP4K1MAPK1MAP3K11KITAAK1 | |
| SCHEMBL7899036 | 0.83 | KIT (0.63) | MAP3K11KITAAK1NTRK1PIK3CA | |
| SCHEMBL7913447 | 0.80 | MAP4K1 (0.56) | MAP4K1MAPK1MAP3K11KIT | |
| SCHEMBL722601 | 0.79 | MAP3K11 (0.58) | MAP4K1MAPK1MAP3K11KITAAK1 | |
| SCHEMBL7903775 | 0.75 | KIT (0.73) | KITAAK1PIK3CA | |
| SCHEMBL7910405 | 0.75 | MAP3K11 (0.62) | MAP3K11 | |
| SCHEMBL7907903 | 0.74 | KIT (0.70) | MAP3K11KITPIK3CA | |
| SCHEMBL12343679 | 0.71 | AAK1 (0.65) | MAP4K1MAPK1MAP3K11KITAAK1 | |
| SCHEMBL28795819 | 0.71 | MAP3K11 (0.58) | MAP4K1MAPK1MAP3K11KITAAK1 | |
| SCHEMBL7910174 | 0.70 | MAP3K11 (0.60) | MAP4K1MAP3K11KITPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |