Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL722011 | 0.84 | KIT (0.56) | MAP4K1KITMAP3K11MAPK1ADORA2A | |
| SCHEMBL7900441 | 0.80 | MAP3K11 (0.66) | MAP3K11ADORA2ALRRK2 | |
| SCHEMBL7908343 | 0.80 | MAP4K1 (0.54) | MAP4K1KITMAP3K11MAPK1 | |
| SCHEMBL7905131 | 0.80 | MAP4K1 (0.54) | MAP4K1KITMAP3K11MAPK1JAK2 | |
| SCHEMBL7905848 | 0.79 | KIT (0.60) | MAP4K1KITIL2 | |
| SCHEMBL7897792 | 0.73 | MAP3K11 (0.74) | MAP3K11LRRK2 | |
| SCHEMBL7094017 | 0.72 | SYK (0.52) | MAPK1LRRK2CHEK1 | |
| SCHEMBL2801860 | 0.71 | JAK2 (0.59) | KITMAP3K11ADORA2AJAK2JAK1 | |
| SCHEMBL12763549 | 0.71 | KIT (0.75) | MAP4K1KITMAP3K11IL2 | |
| SCHEMBL15653841 | 0.70 | MAPK1 (0.48) | MAP4K1KITMAP3K11MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |