Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7896514 | 0.99 | HRH3 (0.42) | HRH3KCNH2ALDH1A1KDM4EKMT2A | |
| SCHEMBL7904663 | 0.92 | MEN1 (0.35) | HRH3KCNH2ALDH1A1KDM4EKMT2A | |
| SCHEMBL7896411 | 0.91 | USP2 (0.43) | HRH3KCNH2ALDH1A1KDM4ECYP2D6 | |
| SCHEMBL7905726 | 0.85 | FLT3 (0.40) | ALDH1A1KDM4EL3MBTL1POLB | |
| SCHEMBL7902622 | 0.85 | KDM4E (0.36) | HRH3ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL7904450 | 0.85 | FLT3 (0.40) | ALDH1A1KDM4EL3MBTL1POLB | |
| SCHEMBL7904730 | 0.84 | FLT3 (0.40) | KDM4ECYP2D6L3MBTL1BACE1LMNA | |
| SCHEMBL7896441 | 0.84 | HTR1B (0.37) | HRH3ALDH1A1KDM4EHTR7 | |
| Hydrochloric Acid SCHEMBL7903914 | 0.83 | HTR1B (0.36) | HRH3ALDH1A1KDM4EHTR7 | |
| SCHEMBL7908577 | 0.83 | FLT3 (0.39) | KDM4ECYP2D6L3MBTL1BACE1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |
| EP-0958294-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS GYOGYSZERGYAR (HU) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030561-A1 | 2-(1,2,4-TRIAZOLE-1-YL)-1,3,4-THIADIAZOLE DERIVATIVES HAVING AN EFFECT ON THE C.N.S. AND THE HEART | EGIS Gyógyszergyár Rt. (HU) | 1998-07-16 | — | — | WO | disclosed |