Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PRNP | P04156 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907870 | 0.85 | CYP3A4 (0.38) | PDE10ACYP3A4SMN1; SMN2 | |
| SCHEMBL9006212 | 0.72 | MAOA (0.48) | CYP3A4CYP1A2 | |
| SCHEMBL2124840 | 0.72 | PIK3CA (0.37) | PDE10ACYP3A4CYP1A2SMN1; SMN2CYP2D6 | |
| SCHEMBL13122195 | 0.68 | ADORA2A (0.46) | PDE10ACYP3A4CYP1A2CYP2C19 | |
| SCHEMBL7902856 | 0.66 | PDE10A (0.42) | PDE10ACYP3A4 | |
| SCHEMBL9006232 | 0.66 | AURKA (0.50) | PDE10ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL24348510 | 0.64 | SMN1; SMN2 (0.58) | CYP1A2SMN1; SMN2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL27101009 | 0.63 | PDE10A (0.36) | PDE10ACYP3A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2123180 | 0.62 | PIK3CA (0.36) | PDE10ACYP3A4CYP1A2SMN1; SMN2CYP2D6 | |
| SCHEMBL18552941 | 0.61 | MEN1 (0.41) | CYP3A4CYP1A2CHEK1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010062559-A1 | SUBSTITUTED PYRAZOLOQUINOLINES AND DERIVATIVES THEREOF | SCHERING CORPORATION (US) | 2010-06-03 | — | — | WO | disclosed |