Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18079552 | 0.86 | AURKA (0.52) | AURKACDK1CDK4CDK2AKT1 | |
| SCHEMBL9006085 | 0.82 | POLB (0.49) | AURKACDK1CDK4CDK2AKT1 | |
| SCHEMBL9006315 | 0.80 | AURKA (0.46) | AURKACDK1CDK4CDK2AKT1 | |
| SCHEMBL9006212 | 0.77 | MAOA (0.48) | AURKAKDM4EHSD17B10NUDT1RAD52 | |
| SCHEMBL12285138 | 0.76 | KDM4E (0.55) | DYRK1AKDM4EHSD17B10LMNASLC2A1 | |
| SCHEMBL9006235 | 0.74 | HPGD (0.49) | AURKACDK1CDK4CDK2AKT1 | |
| SCHEMBL9006179 | 0.74 | PPARA (0.46) | AURKACDK1CDK4CDK2AKT1 | |
| SCHEMBL14478787 | 0.74 | LMNA (0.42) | AURKACDK1CDK4CDK2AKT1 | |
| SCHEMBL7117733 | 0.73 | CYP1A2 (0.65) | KDM4EHSD17B10LMNASLC2A1NQO2 | |
| SCHEMBL22608957 | 0.73 | NUDT1 (0.50) | AURKACDK1CDK4CDK2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9446039-B2 | Aminoheteroaryl compounds as MTH1 inhibitors | CEMM FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2016-09-20 | — | — | US | disclosed |
| US-20160015702-A1 | AMINOHETEROARYL COMPOUNDS AS MTH1 INHIBITORS | CEMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GMBH (AT) | 2016-01-21 | — | — | US | disclosed |
| EP-2892530-A1 | AMINOHETEROARYL COMPOUNDS AS MTH1 INHIBITORS | CeMM - FORSCHUNGSZENTRUM FÜR MOLEKULARE MEDIZIN GmbH (AT) | 2015-07-15 | — | — | EP | disclosed |
| WO-2014033136-A1 | AMINOHETEROARYL COMPOUNDS AS MTH1 INHIBITORS | CEMM - RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES (AT) | 2014-03-06 | — | — | WO | disclosed |
| US-5506236-A | TREATING HERPES VIRUS INFECTIONS | SCHERING CORPORATION | 1996-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160015702-A1 | AMINOHETEROARYL COMPOUNDS AS MTH1 INHIBITORS | MTHFD1, NUDT15, NUDT1 | AURKA 1692/4885CDK1 1615/4885CDK4 2342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.