Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.42 |
| ▸ | PDE6D | O43924 | 4/20 | 0.42 |
| ▸ | PDE6A | P16499 | 4/20 | 0.42 |
| ▸ | PDE6G | P18545 | 4/20 | 0.42 |
| ▸ | PDE6B | P35913 | 4/20 | 0.42 |
| ▸ | PDE6C | P51160 | 4/20 | 0.42 |
| ▸ | PDE6H | Q13956 | 4/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902857 | 0.73 | PDE10A (0.72) | PDE10APDE5A | |
| SCHEMBL7906552 | 0.72 | PDE10A (0.49) | PDE10ACSNK1D | |
| SCHEMBL18079552 | 0.67 | AURKA (0.52) | PDE10A | |
| SCHEMBL7908590 | 0.66 | PDE10A (0.41) | PDE10ACYP3A4 | |
| SCHEMBL9006232 | 0.65 | AURKA (0.50) | PDE10A | |
| SCHEMBL14358249 | 0.64 | UHRF1 (0.38) | PDE10APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL14358256 | 0.64 | PDE10A (0.33) | PDE10APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7907870 | 0.64 | CYP3A4 (0.38) | PDE10APDE5ACYP3A4 | |
| SCHEMBL9006085 | 0.63 | POLB (0.49) | PDE10A | |
| SCHEMBL13219256 | 0.62 | MTNR1A (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010062559-A1 | SUBSTITUTED PYRAZOLOQUINOLINES AND DERIVATIVES THEREOF | SCHERING CORPORATION (US) | 2010-06-03 | — | — | WO | disclosed |