Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 4/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912399 | 1.00 | KMO (0.56) | KMOOPRK1PPARAPPARGCASP1 | |
| SCHEMBL21409003 | 0.85 | PPARA (0.59) | PPARAPPARGCASP1TACR1 | |
| SCHEMBL21409004 | 0.85 | PPARA (0.59) | PPARAPPARGCASP1TACR1 | |
| SCHEMBL7908245 | 0.83 | KMO (0.57) | KMO | |
| SCHEMBL7907186 | 0.83 | KMO (0.57) | KMO | |
| SCHEMBL7443759 | 0.82 | FPR2 (0.60) | OPRK1PPARATACR1 | |
| SCHEMBL7443764 | 0.82 | FPR2 (0.60) | OPRK1PPARATACR1 | |
| SCHEMBL7908730 | 0.80 | GRN (0.60) | KMO | |
| SCHEMBL7907139 | 0.80 | GRN (0.60) | KMO | |
| SCHEMBL4404723 | 0.79 | PPARA (0.55) | PPARAPPARGCASP1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207709-B1 | FOR THERAPY AND PROPHYLAXIS OF NEURODEGENERATIVE DISEASES, SUCH AS HUNTINGTON'S CHOREA, ALZHEIMER'S DISEASE, DEMENTIA CAUSED BY AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFARCTUAL DEMENTIA, CEREBRAL ISCHEMIA, CEREBRAL HYPOXIA, EPILEPSY | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-03-27 | — | — | US | disclosed |