Alpha-Phenyl-Gamma-Butyrolactone

Alpha-Phenyl-Gamma-Butyrolactone

SCHEMBL7909086

O=C1OCC[C@H]1c1ccccc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 4/20 0.44
DDB1 Q16531 1/20 0.43
CRBN Q96SW2 1/20 0.43
CTRB1 P17538 1/20 0.41
CTRC Q99895 1/20 0.40
TSHR P16473 2/20 0.39
CFTR P13569 1/20 0.39
GOPC Q9HD26 1/20 0.39
KMT2A Q03164 1/20 0.39
MAPK1 P28482 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Alpha-Phenyl-Gamma-Butyrolactone SCHEMBL6771142 1.00 CYP19A1 (0.44) CYP19A1DDB1CRBNCTRB1CTRC
Alpha-Phenyl-Gamma-Butyrolactone SCHEMBL576473 1.00 CYP19A1 (0.44) CYP19A1DDB1CRBNCTRB1CTRC
Alpha-Phenyl-Gamma-Butyrolactone SCHEMBL28579210 0.91 CYP19A1 (0.40) CYP19A1DDB1CRBNCTRB1CTRC
SCHEMBL576991 0.88 TP53 (0.42) CYP19A1DDB1CRBNCTRB1CTRC
SCHEMBL576404 0.86 TP53 (0.41) CYP19A1DDB1CRBNCTRB1CTRC
Alpha-Phenyl-Gamma-Butyrolactone SCHEMBL28588955 0.84 CYP19A1 (0.43) CYP19A1DDB1CRBNCTRB1
Alpha-Phenyl-Gamma-Butyrolactone SCHEMBL28591531 0.83 ALDH1A1 (0.51) CYP19A1DDB1CRBNCTRB1CTRC
SCHEMBL6461863 0.80 ALOX12 (0.45) CYP19A1KMT2AMAPK1
SCHEMBL10393997 0.80 TP53 (0.42) CYP19A1KMT2A
SCHEMBL576857 0.80 CYP19A1 (0.45) CYP19A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207862-B1 PRECURSORS ARE CHIRAL 4-HYDROXYCARBOXAMIDES, 4-HYDROXYHYDROXAMIC ACIDS, OR 4-HYDROXYHYDRAZIDES PRODUCED FROM GAMMA-LACTONES, WHICH IN TURN ARE DERIVED FROM 1,4-DIOLS BY STEREOSELECTIVE OXIDATION, BIOCATALYTICS, INC. 2001-03-27 US disclosed
WO-1999032649-A1 METHODS AND PRECURSORS FOR THE PRODUCTION OF CHIRAL 1,3-AMINOALCOHOLS BIOCATALYTICS, INC. (US) 1999-07-01 WO disclosed
US-5916786-A Method for the production of chiral 1,3-aminoalcohols BIOCATALYTICS, INC. (US) 1999-06-29 US disclosed