Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 7/20 | 0.47 |
| ▸ | FNTA | P49354 | 2/20 | 0.45 |
| ▸ | FNTB | P49356 | 2/20 | 0.45 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | ALB | P02768 | 2/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | NMT2 | O60551 | 1/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.43 |
| ▸ | GNPAT | O15228 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225493 | 1.00 | SLC6A5 (0.51) | SLC6A5FOLH1NOD1FNTAFNTB | |
| SCHEMBL8201903 | 0.87 | KMT2A (0.49) | SLC6A5NOD1EPHX2SIRT6SIRT1 | |
| SCHEMBL7911445 | 0.83 | FOLH1 (0.52) | FOLH1SIRT6SIRT1 | |
| SCHEMBL7227342 | 0.83 | FOLH1 (0.52) | FOLH1SIRT6SIRT1 | |
| SCHEMBL7901699 | 0.82 | FOLH1 (0.49) | FOLH1NOD1EPHX2ALB | |
| SCHEMBL232587 | 0.81 | SLC6A5 (0.65) | SLC6A5FOLH1NOD1NMT2NMT1 | |
| SCHEMBL232527 | 0.81 | SLC6A5 (0.65) | SLC6A5FOLH1NOD1NMT2NMT1 | |
| SCHEMBL7225427 | 0.80 | FOLH1 (0.43) | FOLH1SIRT6SIRT1 | |
| SCHEMBL7912042 | 0.80 | FOLH1 (0.43) | FOLH1SIRT6SIRT1 | |
| SCHEMBL7227075 | 0.78 | NOD1 (0.50) | FOLH1NOD1FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207708-B1 | FOR THERAPY AND PROPHYLAXIS OF AUTOIMMUNE AND/OR INFLAMMATORY CONDITIONS AFFECTING THE JOINTS SUCH AS ARTHRITIS, AND INFLAMMATORY BOWEL DISEASE, CARDIVASCULAR ISCHEMIA, DIABETES, CONGESTIVE HEART FAILURE, MYOCARDITIS, ATHEROSCLEROSIS, | G. D. SEARLE & COMPANY | 2001-03-27 | — | — | US | claimed |
| EP-0885188-B1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2000-09-27 | — | — | EP | claimed |
| EP-0885188-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-12-23 | — | — | EP | claimed |
| WO-1997032844-A9 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | — | 1997-12-24 | — | — | WO | claimed |
| WO-1997032844-A1 | HYDROXYAMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-09-12 | — | — | WO | claimed |