Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | RXRB | P28702 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913287 | 0.87 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL7912981 | 0.84 | ALDH1A1 (0.51) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL7916727 | 0.80 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL7910346 | 0.78 | KDM4E (0.67) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL7913027 | 0.78 | KDM4E (0.67) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL8127248 | 0.77 | RAB9A (0.41) | KDM4ERXRBALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2899414 | 0.76 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL7910307 | 0.76 | KDM4E (0.64) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL7903030 | 0.75 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG | |
| SCHEMBL2899565 | 0.75 | KDM4E (0.73) | KDM4EALDH1A1SMN1; SMN2KMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258829-B1 | ANTIARRTHMIA AGENTS AND CARDIOVASCULAR DISORDERS | TOA EIYO LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0972767-A1 | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME | TOA EIYO LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |